产品
编 号：F043306
分子式：C19H25ClN2
分子量：316.87
分子式：C19H25ClN2
分子量：316.87
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 113-52-0
产品详情
生物活性：
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.
体内研究：
Imipramine (20 mg/kg, i.p. or 15 mg/kg, p.o.; daily for 24 days) attenuates neuroinflammatory signaling and reverses stress-induced social avoidance in mice.Animal Model:Male C57BL/6 mice (6–8 weeks old) subjected to RSD (repeated social defeat) and HCC (home cage control)
Dosage:20 mg/kg or 15 mg/kg
Administration:Intraperitoneal injection or oral administration, daily for 24 days
Result:Reversed RSD-induced social avoidance behavior, significantly increasing the interaction time, significantly decreased stress-induced mRNA levels for IL-6 in brain microglia.
体外研究：
Imipramine (0.5-300 μM, 3 days) inhibits HCT-116 cell viability.?Imipramine (20 μM) inhibits cell migration (7 h) and invasion (48 h).?Imipramine (50 μM, 0-240 min) inhibites the PI3K/Akt/mTOR signaling pathway in U-87MG glioma cells.?Imipramine (60 μM, 24 h) stimulates U-87MG glioma cells autophagy.?Imipramine (80 μM, 24 h) induces HL-60 cell apoptosis.
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.
体内研究：
Imipramine (20 mg/kg, i.p. or 15 mg/kg, p.o.; daily for 24 days) attenuates neuroinflammatory signaling and reverses stress-induced social avoidance in mice.Animal Model:Male C57BL/6 mice (6–8 weeks old) subjected to RSD (repeated social defeat) and HCC (home cage control)
Dosage:20 mg/kg or 15 mg/kg
Administration:Intraperitoneal injection or oral administration, daily for 24 days
Result:Reversed RSD-induced social avoidance behavior, significantly increasing the interaction time, significantly decreased stress-induced mRNA levels for IL-6 in brain microglia.
体外研究：
Imipramine (0.5-300 μM, 3 days) inhibits HCT-116 cell viability.?Imipramine (20 μM) inhibits cell migration (7 h) and invasion (48 h).?Imipramine (50 μM, 0-240 min) inhibites the PI3K/Akt/mTOR signaling pathway in U-87MG glioma cells.?Imipramine (60 μM, 24 h) stimulates U-87MG glioma cells autophagy.?Imipramine (80 μM, 24 h) induces HL-60 cell apoptosis.
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