产品
编 号：F385035
分子式：C8H20ClNO
分子量：181.7
分子式：C8H20ClNO
分子量：181.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 543-15-7
产品详情
生物活性：
Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels.
体内研究：
Heptaminol hydrochloride (12 μL; 50% water/acetone) 局部预处理，可通过刺激组成型 NOS 合成 NO 来减轻 TPA 诱导的小鼠耳朵边缘 NK 细胞的消耗。Heptaminol hydrochloride 对 TPA 的抗增生和抗炎作用暗示了重要的抗肿瘤功能。Animal Model:Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)
Dosage:2.5 nmol Heptaminol in 12 μL
Administration:Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment.
Result:Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels.
体内研究：
Heptaminol hydrochloride (12 μL; 50% water/acetone) 局部预处理，可通过刺激组成型 NOS 合成 NO 来减轻 TPA 诱导的小鼠耳朵边缘 NK 细胞的消耗。Heptaminol hydrochloride 对 TPA 的抗增生和抗炎作用暗示了重要的抗肿瘤功能。Animal Model:Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)
Dosage:2.5 nmol Heptaminol in 12 μL
Administration:Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment.
Result:Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
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