产品
编 号：F384942
分子式：C19H18F5NO4
分子量：419.34
分子式：C19H18F5NO4
分子量：419.34
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CAS No: 54280-71-6
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生物活性：
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand.
体外研究：
Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (μM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants.Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death.
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand.
体外研究：
Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (μM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants.Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death.
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