产品
编 号：F384821
分子式：C12H17N3O
分子量：219.28
分子式：C12H17N3O
分子量：219.28
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 54239-37-1
产品详情
生物活性：
Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM).
体内研究：
Cimaterol stimulates skeletal muscle gain in ob/ob mice.Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level.Animal Model:One hundred fifty crossbred pigs (55 kg)
Dosage:Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
Administration:
Result:Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
体外研究：
Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM).Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 μM) shows a significant increase of cAMP concentration subsequent drug exposure.
Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM).
体内研究：
Cimaterol stimulates skeletal muscle gain in ob/ob mice.Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level.Animal Model:One hundred fifty crossbred pigs (55 kg)
Dosage:Corn-soybean meal-based diets (.65% lysine) with 0, 0.25 and 0.5 mg/kg
Administration:
Result:Pigs fed 0.25 mg/kg with a 1-d drug withdrawal had 6.8, 7.7 and 13.5% less 10th rib fat depth and 11.1, 6.1 and 13.3% less P2 fat depth than those subjected to either a 3- or 5-d drug withdrawal or those fed the 0 mg/kg cimaterol diet (control), respectively.Resulted in higher Warner-Bratzler shear force values and altered the proportion of saturation in some long-chain fatty acids at 0.5 mg/kg.
体外研究：
Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM).Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 μM) shows a significant increase of cAMP concentration subsequent drug exposure.
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