产品
编 号：F383815
分子式：C20H16O4
分子量：320.34
分子式：C20H16O4
分子量：320.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 53947-92-5
产品详情
生物活性：
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.
体内研究：
Corylin (60 mg/kg，腹腔注射，每周 3 次，4 周) 可抑制 Huh7 细胞异种移植小鼠肿瘤生长。Corylin (50-100 mg/kg，口服，每日一次，9 周) 可改善 HFD 和 DIO 处理的小鼠的高脂饮食 (HFD) 诱导的肥胖。Animal Model:HFD- and DIO-treated mice
Dosage:50-100 mg/kg
Administration:Oral gavage (p.o.), daily, 9 weeks
Result:Reduced the weight of subcutaneous, visceral WAT, and body.Decreased the size of WAT adipocyte.Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.Reduced serum levels of insulin and leptin and improved HOMA-IR.
体外研究：
Corylin (3-300 μM，0-72 h) 抑制 HepG2 和 Huh7 细胞的增殖。Corylin (3-30 μM，0-48 h) 通过抑制 EMT 来抑制 HepG2 和 Huh7 细胞的迁移和侵袭。Corylin (5-200 μM，24 h) 在 100-200 μM 剂量下会降低 3T3-L1 前脂肪细胞的活力。Corylin (10 μM，24 h) 通过 SIRT1 和 β3-AR 途径诱导 3T3-L1 脂肪细胞褐变。
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.
体内研究：
Corylin (60 mg/kg，腹腔注射，每周 3 次，4 周) 可抑制 Huh7 细胞异种移植小鼠肿瘤生长。Corylin (50-100 mg/kg，口服，每日一次，9 周) 可改善 HFD 和 DIO 处理的小鼠的高脂饮食 (HFD) 诱导的肥胖。Animal Model:HFD- and DIO-treated mice
Dosage:50-100 mg/kg
Administration:Oral gavage (p.o.), daily, 9 weeks
Result:Reduced the weight of subcutaneous, visceral WAT, and body.Decreased the size of WAT adipocyte.Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.Reduced serum levels of insulin and leptin and improved HOMA-IR.
体外研究：
Corylin (3-300 μM，0-72 h) 抑制 HepG2 和 Huh7 细胞的增殖。Corylin (3-30 μM，0-48 h) 通过抑制 EMT 来抑制 HepG2 和 Huh7 细胞的迁移和侵袭。Corylin (5-200 μM，24 h) 在 100-200 μM 剂量下会降低 3T3-L1 前脂肪细胞的活力。Corylin (10 μM，24 h) 通过 SIRT1 和 β3-AR 途径诱导 3T3-L1 脂肪细胞褐变。
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