产品
编 号：F383276
分子式：C11H15BrN2O
分子量：271.15
分子式：C11H15BrN2O
分子量：271.15
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 537672-41-6
产品详情
生物活性：
UF010 is a selective inhibitor of class I HDAC. UF010 has cytotoxicity to cancer cells and reduces neuroinflammation in the hippocampus. UF010 can be used for the research of neurological diseases.
体内研究：
UF010 (15 mg/kg，腹腔注射，单次剂量) 对术后认知功能障碍 (POCD) 小鼠海马神经元具有显著的炎症调节作用。UF010 (15 mg/kg，腹腔注射，单次剂量) 在 4T1-Luc 荷瘤小鼠模型中具有抗肿瘤治疗作用。Animal Model:postoperative cognitive dysfunction (POCD) mice
Dosage:15 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Weakened the infiltration of CD4+ T cells and NK cells in hippocampal tissues.Reduced inflammatory parameters in serum and hippocampal tissues, such as interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor alpha (TNF-α) levels.Activated the NF-κB/p65, JAK/STAT and TLR/MyD88 pathways.
Animal Model:4T1-Luc tumor-bearing mouse model
Dosage:15 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited the tumor growth rate percentage to 55.56, 38.36, 39.52% at days 7, 14, and 21.Induced high levels of ROS generation, causing apoptosis-mediated tumor cell death.
体外研究：
UF010 (500 nM, 4 days) 导致杆状细胞产量显著减少，同时 Müller 细胞增加。UF010 (10-100 μM, 72 h) 对 B16F10 细胞、MCF-7 细胞、A549 细胞、4T1 细胞、HEK-293 细胞和 HCEC 细胞有细胞毒性。
UF010 is a selective inhibitor of class I HDAC. UF010 has cytotoxicity to cancer cells and reduces neuroinflammation in the hippocampus. UF010 can be used for the research of neurological diseases.
体内研究：
UF010 (15 mg/kg，腹腔注射，单次剂量) 对术后认知功能障碍 (POCD) 小鼠海马神经元具有显著的炎症调节作用。UF010 (15 mg/kg，腹腔注射，单次剂量) 在 4T1-Luc 荷瘤小鼠模型中具有抗肿瘤治疗作用。Animal Model:postoperative cognitive dysfunction (POCD) mice
Dosage:15 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Weakened the infiltration of CD4+ T cells and NK cells in hippocampal tissues.Reduced inflammatory parameters in serum and hippocampal tissues, such as interleukin 6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor alpha (TNF-α) levels.Activated the NF-κB/p65, JAK/STAT and TLR/MyD88 pathways.
Animal Model:4T1-Luc tumor-bearing mouse model
Dosage:15 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited the tumor growth rate percentage to 55.56, 38.36, 39.52% at days 7, 14, and 21.Induced high levels of ROS generation, causing apoptosis-mediated tumor cell death.
体外研究：
UF010 (500 nM, 4 days) 导致杆状细胞产量显著减少，同时 Müller 细胞增加。UF010 (10-100 μM, 72 h) 对 B16F10 细胞、MCF-7 细胞、A549 细胞、4T1 细胞、HEK-293 细胞和 HCEC 细胞有细胞毒性。
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