产品
编 号：F383263
分子式：C30H39NO5
分子量：493.63
分子式：C30H39NO5
分子量：493.63
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结构图
CAS No: 53760-19-3
产品详情
生物活性：
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity.
体内研究：
Cytochalasin H (2.5 mg/kg; i.p.) 可以延迟 Balb/cnu/nu 小鼠中 A549 异种移植肿瘤的生长。Animal Model:male Balb/cnu/nu mice with A549 xenograft
Dosage:2.5 mg/kg
Administration:intraperitoneal injection; 3 injections/week,for 80 days
Result:Attenuated tumor growth in vivo.
体外研究：
Cytochalasin H (24-72 h) 抑制 A549 细胞的增殖，IC50 值为 159.5 μM。Cytochalasin H (0-50 μM; 48 h) 在 A549 细胞中诱导细胞凋亡，使细胞周期停滞在 G2/M 期，并影响细胞凋亡相关蛋白的表达。Cytochalasin H (1-512 μg/mL) 对 MDR 肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性。
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity.
体内研究：
Cytochalasin H (2.5 mg/kg; i.p.) 可以延迟 Balb/cnu/nu 小鼠中 A549 异种移植肿瘤的生长。Animal Model:male Balb/cnu/nu mice with A549 xenograft
Dosage:2.5 mg/kg
Administration:intraperitoneal injection; 3 injections/week,for 80 days
Result:Attenuated tumor growth in vivo.
体外研究：
Cytochalasin H (24-72 h) 抑制 A549 细胞的增殖，IC50 值为 159.5 μM。Cytochalasin H (0-50 μM; 48 h) 在 A549 细胞中诱导细胞凋亡，使细胞周期停滞在 G2/M 期，并影响细胞凋亡相关蛋白的表达。Cytochalasin H (1-512 μg/mL) 对 MDR 肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性。
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