产品
编 号：F382996
分子式：C19H32N4O11
分子量：492.48
分子式：C19H32N4O11
分子量：492.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 53678-77-6
产品详情
生物活性：
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist.
体内研究：
Muramyl dipeptide (1.25 mg/kg；腹腔注射；两次) 减轻骨质疏松症引起的骨质流失。Animal Model:RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)
Dosage:1.25 mg/kg
Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result:Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).
体外研究：
Muramyl dipeptide (0.1-10 μg/mL；24 hours) 以剂量依赖性方式增加 Runx2 的蛋白表达。Muramyl dipeptide (0.1-10 μg/mL；6 小时) 以剂量依赖性方式增加 Runx2 的 mRNA 水平。Muramyl dipeptide 通过降低 RANKL/OPG 比率间接减弱破骨细胞分化。
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist.
体内研究：
Muramyl dipeptide (1.25 mg/kg；腹腔注射；两次) 减轻骨质疏松症引起的骨质流失。Animal Model:RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)
Dosage:1.25 mg/kg
Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)
Result:Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).
体外研究：
Muramyl dipeptide (0.1-10 μg/mL；24 hours) 以剂量依赖性方式增加 Runx2 的蛋白表达。Muramyl dipeptide (0.1-10 μg/mL；6 小时) 以剂量依赖性方式增加 Runx2 的 mRNA 水平。Muramyl dipeptide 通过降低 RANKL/OPG 比率间接减弱破骨细胞分化。
产品资料
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