产品
编 号：F382939
分子式：C19H22N4O3
分子量：354.4
分子式：C19H22N4O3
分子量：354.4
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 53671-71-9
产品详情
生物活性：
ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.
体内研究：
Animal Model:Rats.
Dosage:0.6, 5 or 50 mg/kg.
Administration:Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result:Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.
体内研究：
Animal Model:Rats.
Dosage:0.6, 5 or 50 mg/kg.
Administration:Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result:Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
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