产品
编 号：F382843
分子式：C18H28ClNO2
分子量：325.87
分子式：C18H28ClNO2
分子量：325.87
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
5g
询价
询价
10g
询价
询价
结构图
CAS No: 536-43-6
产品详情
生物活性：
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
体内研究：
Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.Animal Model:Athymic nude mice (HSC-2 cells implanted model).
Dosage:5 mg/kg
Administration:Intraperitoneal injection; single daily for 24 days (combine with sulfasalazine).
Result:Attenuated the formation of tumors by HSC-2 cells implanted in nude mice when combined with sulfasalazine.
Animal Model:C57BL6 mice (K19-Wnt1/C2mE-KP cells implanted model).
Dosage:5 mg/kg
Administration:Intraperitoneal injection; single daily for 21 days (combine with sulfasalazine).
Result:Enhanced the antitumor effect of sulfasalazine on HNSCC tumors consisting of CD44vhigh stemlike tumor cells and involucrin+ differentiated tumor cells.
体外研究：
Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity.
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
体内研究：
Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.Animal Model:Athymic nude mice (HSC-2 cells implanted model).
Dosage:5 mg/kg
Administration:Intraperitoneal injection; single daily for 24 days (combine with sulfasalazine).
Result:Attenuated the formation of tumors by HSC-2 cells implanted in nude mice when combined with sulfasalazine.
Animal Model:C57BL6 mice (K19-Wnt1/C2mE-KP cells implanted model).
Dosage:5 mg/kg
Administration:Intraperitoneal injection; single daily for 21 days (combine with sulfasalazine).
Result:Enhanced the antitumor effect of sulfasalazine on HNSCC tumors consisting of CD44vhigh stemlike tumor cells and involucrin+ differentiated tumor cells.
体外研究：
Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity.
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