产品
编 号:F381983
分子式:C24H32O6
分子量:416.51
产品类型
结构图
CAS No: 53-36-1
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生物活性:
Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
体内研究:
Methylprednisolone acetate (30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days)combines with LPS induces typical features of early AVN of the femoral head.Animal Model:A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide
Dosage:30 mg/kg; 13 mg/kg for 10 consecutive days
Administration:30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days
Result:Lead to chondrocyte degeneration and fibrocartilage expression after 7 weeks.Increased the density of CD31 and VEGF-R2 markers in the femoral head.