产品
编 号：F381734
分子式：C16H18N6O4
分子量：358.35
分子式：C16H18N6O4
分子量：358.35
产品类型
规格
价格
是否有货
5mg
询价
询价
结构图
CAS No: 53296-10-9
产品详情
生物活性：
CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.
体内研究：
Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles.Animal Model:Male Sprague-Dawley rat, weighing 370-410 g
Dosage:0.002, 0.02, 0.2, and 2 μM
Administration:Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result:Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
体外研究：
CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM.In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM.
CV1808?(2-Phenylaminoadenosine) is a non-selective A2?adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.
体内研究：
Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles.Animal Model:Male Sprague-Dawley rat, weighing 370-410 g
Dosage:0.002, 0.02, 0.2, and 2 μM
Administration:Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result:Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
体外研究：
CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM.In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM.
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