产品
编 号：F381730
分子式：C17H23N5O2S
分子量：361.46
分子式：C17H23N5O2S
分子量：361.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
2950
In-stock
1mg
900
In-stock
5mg
1960
In-stock
10mg
3120
In-stock
25mg
6240
In-stock
结构图
CAS No: 532959-63-0
产品详情
生物活性：
PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer.
体内研究：
PF-4878691 (10-150 mg, Oral gavage, single dose) 诱导 BALB/c 小鼠和 C57bl/6 j 小鼠的药理学作用。Animal Model:BALB/c mice , C57bl/6 J mice
Dosage:30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg
Administration:Oral gavage (p.o.)
Result:Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).Caused cardiovascular changes. Significantly increased TLR7 receptor RNA.
体外研究：
PF-4878691 (10 μM, 4 h) 诱导复杂的转录网络，负责激活浆细胞样树突状细胞的固有抗病毒免疫应答，优化对 RNA 病毒的应答，增加共刺激能力，并增加浆细胞样树突状细胞的存活率。
PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer.
体内研究：
PF-4878691 (10-150 mg, Oral gavage, single dose) 诱导 BALB/c 小鼠和 C57bl/6 j 小鼠的药理学作用。Animal Model:BALB/c mice , C57bl/6 J mice
Dosage:30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg
Administration:Oral gavage (p.o.)
Result:Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).Caused cardiovascular changes. Significantly increased TLR7 receptor RNA.
体外研究：
PF-4878691 (10 μM, 4 h) 诱导复杂的转录网络，负责激活浆细胞样树突状细胞的固有抗病毒免疫应答，优化对 RNA 病毒的应答，增加共刺激能力，并增加浆细胞样树突状细胞的存活率。
产品资料
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