产品
编 号:F381410
分子式:C11H15NO5
分子量:241.24
产品类型
结构图
CAS No: 532-03-6
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产品详情
生物活性:
Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.
体内研究:
Methocarbamol (200?mg/kg; ip) has Muscle relaxant activity of 88.96%.Animal Model:Mice with weight 20-30?g
Dosage:200?mg/kg
Administration:IP; single dose
Result:Had Muscle relaxant activity of 88.96%.
体外研究:
Methocarbamol (2?mM; for 20?min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation.Methocarbamol has no effect on Nav1.7 currents.