产品
编 号：F381349
分子式：C16H14ClMnN2O2
分子量：356.69
分子式：C16H14ClMnN2O2
分子量：356.69
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
200
In-stock
10mg
320
In-stock
结构图
CAS No: 53177-12-1
产品详情
生物活性：
Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.
体内研究：
Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice
Dosage:25 mg/kg/day
Administration:I.p. 3 times a week for 4 weeks
Result:Prevented myocardial oxidant damage provoked by biomechanical stress.Improved survival following biomechanical stress.Prevented functional and geometrical deterioration in response to pressure overload.Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
体外研究：
Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.
Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.
体内研究：
Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice
Dosage:25 mg/kg/day
Administration:I.p. 3 times a week for 4 weeks
Result:Prevented myocardial oxidant damage provoked by biomechanical stress.Improved survival following biomechanical stress.Prevented functional and geometrical deterioration in response to pressure overload.Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
体外研究：
Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备