产品
编 号：F381298
分子式：C26H29ClO16
分子量：632.95
分子式：C26H29ClO16
分子量：632.95
产品类型
规格
价格
是否有货
结构图
CAS No: 53158-73-9
产品详情
生物活性：
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
体内研究：
Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS.Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats.Animal Model:Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿.Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累。
Dosage:15 μmol/kg
Administration:Intraperitoneal injection (i.p.), for 4 days.
Result:Reduced the LPS-induced paw thickness. Decreased the edema by 89.3%.Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
Animal Model:HFD-fed rats
Dosage:30 mg/kg
Administration:Oral gavage, daily for eight weeks.
Result:Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
体外研究：
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells.Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells.Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells.Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM.Delphinidin-3-sambubioside chloride (100-200 μg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells.
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
体内研究：
Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS.Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats.Animal Model:Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿.Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累。
Dosage:15 μmol/kg
Administration:Intraperitoneal injection (i.p.), for 4 days.
Result:Reduced the LPS-induced paw thickness. Decreased the edema by 89.3%.Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
Animal Model:HFD-fed rats
Dosage:30 mg/kg
Administration:Oral gavage, daily for eight weeks.
Result:Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
体外研究：
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells.Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells.Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells.Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM.Delphinidin-3-sambubioside chloride (100-200 μg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备