产品
编 号：F380492
分子式：C27H44O7
分子量：480.63
分子式：C27H44O7
分子量：480.63
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
280
In-stock
10mg
400
In-stock
50mg
1600
In-stock
100mg
2560
In-stock
结构图
CAS No: 5289-74-7
产品详情
生物活性：
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).
体内研究：
Crustecdysone (5 或 10 mg/kg；腹腔注射，每天一次，持续 6 周) 降低自发性高血压大鼠的血压，并防止扩张性心肌肥厚。Animal Model:Male spontaneous hypertensive (SHR) rats
Dosage:5 or 10 mg/kg
Administration:Intraperitoneal injection; 5 or 10 mg/kg , once daily, for 6 weeks
Result:Decreased seminal vesicular weight, systolic pressure, and left ventricular dilatation caused by hypertension. Increased testicular weight and amount of β-isoform.
体外研究：
Crustecdysone 在果蝇重塑脂肪体过程中诱导细胞自噬和 caspase-3 活性。
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).
体内研究：
Crustecdysone (5 或 10 mg/kg；腹腔注射，每天一次，持续 6 周) 降低自发性高血压大鼠的血压，并防止扩张性心肌肥厚。Animal Model:Male spontaneous hypertensive (SHR) rats
Dosage:5 or 10 mg/kg
Administration:Intraperitoneal injection; 5 or 10 mg/kg , once daily, for 6 weeks
Result:Decreased seminal vesicular weight, systolic pressure, and left ventricular dilatation caused by hypertension. Increased testicular weight and amount of β-isoform.
体外研究：
Crustecdysone 在果蝇重塑脂肪体过程中诱导细胞自噬和 caspase-3 活性。
产品资料
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