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编 号:F380004
分子式:C20H28O
分子量:284.44
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25mg
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50mg
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100mg
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生物活性:
Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 μM for hPXR and zfPXR, respectively. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties.

体内研究:
Lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells. Lynestrenol is studied at three different doses (6.87, 13.75 and 27.50 mg/kg). Sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) increase significantly as compared to normal control when treated with Lynestrenol at 13.75 and 27.50 mg/kg.

体外研究:
Lynestrenol markedly enhances the lymphocyte response to phytohemagglutinin, the mixed lymphocyte culture, the active T-rosette test, the autologous red cell rosettes, and the number of nonadherent cells in the leukocyte adherence inhibition test. Lynestrenol also increases monocyte phagocytosis. Lynestrenol delays the appearance of malignant tumors in hamsters.
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