产品
编 号：F379732
分子式：C5H11NO2S
分子量：149.21
分子式：C5H11NO2S
分子量：149.21
产品类型
规格
价格
是否有货
100mg
400
In-stock
结构图
CAS No: 52-67-5
产品详情
生物活性：
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
体内研究：
Penicillamine (D-(-)-Penicillamine) (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases serum free copper concentration.Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases ATP7A and CTR1 mRNA expression in the brain of tx mice.Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) induces oxidative-stress in the central nervous system.Penicillamine (0.1-250 mg/kg; i.p.; once, for 90 min; male NMRI mice) has binaural phase effect on seizure.Penicillamine (5 mg/kg; i.v.; daily, for 8 weeks; male BN rats) prevents the onset of autoimmunity at a low dose.Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the free copper concentrations in the tx mice serum on the 3rd day.
Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the mRNA expression of ATP7A by 4-fold. Increased CTR1 mRNA expression by 6.9-fold in the cortex and 9.1-fold in the basal ganglia of tx mice.
Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the concentration of MDA and decreased GSH/GSSG ratios through nitric oxide/NMDA pathways.
Animal Model:Male NMRI mice
Dosage:0.1, 0.5, 1, 10, 100, 150 and 250 mg/kg
Administration:Intraperitoneal injection; once, for 90 minutes
Result:Had anticonvulsant effects at a low dose (0.5 mg/kg) and had anticonvulsant effects at a high dose (250 mg/kg). Reversed the anti- and proconvulsant effects by acute pretreatment of L-NAME (a nonselective nitric oxide synthase inhibitor) and 7-NI (a selective neuronal nitric oxide synthase inhibitor).
Animal Model:Male BN rats
Dosage:5 mg/kg
Administration:Intravenous injection; daily, for 8 weeks
Result:Inhibited IgE upregulation and prevented the onset of autoimmunity.
体外研究：
Penicillamine (D-(-)-Penicillamine) (5 mg; 7 d; CD4+ and CD+ splenocytes) promotes cellular immune responses.
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
体内研究：
Penicillamine (D-(-)-Penicillamine) (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases serum free copper concentration.Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases ATP7A and CTR1 mRNA expression in the brain of tx mice.Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) induces oxidative-stress in the central nervous system.Penicillamine (0.1-250 mg/kg; i.p.; once, for 90 min; male NMRI mice) has binaural phase effect on seizure.Penicillamine (5 mg/kg; i.v.; daily, for 8 weeks; male BN rats) prevents the onset of autoimmunity at a low dose.Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the free copper concentrations in the tx mice serum on the 3rd day.
Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the mRNA expression of ATP7A by 4-fold. Increased CTR1 mRNA expression by 6.9-fold in the cortex and 9.1-fold in the basal ganglia of tx mice.
Animal Model:Toxic milk mutant mice (tx mice) and DL mice
Dosage:200 mg/kg
Administration:Oral gavage; daily, for 3, 10 and 14 days
Result:Increased the concentration of MDA and decreased GSH/GSSG ratios through nitric oxide/NMDA pathways.
Animal Model:Male NMRI mice
Dosage:0.1, 0.5, 1, 10, 100, 150 and 250 mg/kg
Administration:Intraperitoneal injection; once, for 90 minutes
Result:Had anticonvulsant effects at a low dose (0.5 mg/kg) and had anticonvulsant effects at a high dose (250 mg/kg). Reversed the anti- and proconvulsant effects by acute pretreatment of L-NAME (a nonselective nitric oxide synthase inhibitor) and 7-NI (a selective neuronal nitric oxide synthase inhibitor).
Animal Model:Male BN rats
Dosage:5 mg/kg
Administration:Intravenous injection; daily, for 8 weeks
Result:Inhibited IgE upregulation and prevented the onset of autoimmunity.
体外研究：
Penicillamine (D-(-)-Penicillamine) (5 mg; 7 d; CD4+ and CD+ splenocytes) promotes cellular immune responses.
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