产品
编 号：F379490
分子式：C15H14N4O2S
分子量：314.36
分子式：C15H14N4O2S
分子量：314.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 526-08-9
产品详情
生物活性：
Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion.
体内研究：
Sulfaphenazole (5.13 mg/kg；腹腔给药；每天；8周) 可恢复糖尿病小鼠的内皮介导的松弛。Animal Model:Diabetic male mice (db/db strain)
Dosage:5.13 mg/kg
Administration:Intraperitoneal injections; daily; for 8 weeks
Result:Although sulfaphenazole did not change endothelium-dependent vasodilation in control mice, it restored endothelium-mediated relaxation in db/db mice.
体外研究：
Sulfaphenazole (10 μM；1个小时) 使光诱导的凋亡细胞和坏死细胞的数量分别减少 33% 和 44%。
Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion.
体内研究：
Sulfaphenazole (5.13 mg/kg；腹腔给药；每天；8周) 可恢复糖尿病小鼠的内皮介导的松弛。Animal Model:Diabetic male mice (db/db strain)
Dosage:5.13 mg/kg
Administration:Intraperitoneal injections; daily; for 8 weeks
Result:Although sulfaphenazole did not change endothelium-dependent vasodilation in control mice, it restored endothelium-mediated relaxation in db/db mice.
体外研究：
Sulfaphenazole (10 μM；1个小时) 使光诱导的凋亡细胞和坏死细胞的数量分别减少 33% 和 44%。
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