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编 号：F379083
分子式：C22H27NO
分子量：321.46
分子式：C22H27NO
分子量：321.46
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CAS No: 524-83-4
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生物活性：
Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent.
体内研究：
Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits.Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs.Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats.Animal Model:Dogs with cardiac arrhythmias
Dosage:30-60 μg/kg
Administration:Administered by the fourth ventricle
Result:Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.Converted arrhythmias to sinus rhythms.
体外研究：
Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.
Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent.
体内研究：
Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits.Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs.Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats.Animal Model:Dogs with cardiac arrhythmias
Dosage:30-60 μg/kg
Administration:Administered by the fourth ventricle
Result:Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.Converted arrhythmias to sinus rhythms.
体外研究：
Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.
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