产品
编 号：F378997
分子式：C26H26F2N2
分子量：404.49
分子式：C26H26F2N2
分子量：404.49
产品类型
规格
价格
是否有货
50mg
询价
询价
结构图
CAS No: 52468-60-7
产品详情
生物活性：
Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
体内研究：
Flunarizine (intraperitoneal injection; 30?mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI).Animal Model:Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide
Dosage:30?mg/kg
Administration:Intraperitoneal injection; 30?mg/kg; once
Result:Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release.Inhibited the pulmonary inflammation.
体外研究：
Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively.Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells.Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM.
Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
体内研究：
Flunarizine (intraperitoneal injection; 30?mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI).Animal Model:Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide
Dosage:30?mg/kg
Administration:Intraperitoneal injection; 30?mg/kg; once
Result:Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release.Inhibited the pulmonary inflammation.
体外研究：
Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively.Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells.Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM.
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