产品
编 号：F378722
分子式：C21H28O5
分子量：360.44
分子式：C21H28O5
分子量：360.44
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规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
询价
询价
10mg
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询价
结构图
CAS No: 52-39-1
产品详情
生物活性：
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.
体内研究：
Aldosterone (1 mg/Kg+1% NaCl；ih；每天一次，持续 3 周) 显著增加收缩压 (SBP)、舒张压 (DBP)、左心室收缩压 (LVSP) 和左心室舒张末压 (LVEDP)。 Aldosterone (0.72 mg/kg/天；14 天) 导致雄性小鼠血压小幅升高 (14 mmHg)。Animal Model:Forty male Wistar rats
Dosage:1 mg/Kg (+1% NaCl)
Administration:i.h.; once daily for 3 weeks
Result:Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
体外研究：
Aldosterone (1-1000 nM；24 小时) 以剂量依赖性方式抑制血管平滑肌细胞白细胞介素-1β 刺激的亚硝酸盐生成。
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.
体内研究：
Aldosterone (1 mg/Kg+1% NaCl；ih；每天一次，持续 3 周) 显著增加收缩压 (SBP)、舒张压 (DBP)、左心室收缩压 (LVSP) 和左心室舒张末压 (LVEDP)。 Aldosterone (0.72 mg/kg/天；14 天) 导致雄性小鼠血压小幅升高 (14 mmHg)。Animal Model:Forty male Wistar rats
Dosage:1 mg/Kg (+1% NaCl)
Administration:i.h.; once daily for 3 weeks
Result:Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
体外研究：
Aldosterone (1-1000 nM；24 小时) 以剂量依赖性方式抑制血管平滑肌细胞白细胞介素-1β 刺激的亚硝酸盐生成。
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