产品
编 号：F378631
分子式：C14H12O3
分子量：228.24
分子式：C14H12O3
分子量：228.24
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 523-59-1
产品详情
生物活性：
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.
体内研究：
Seselin (0.5-40.5 mg/kg; s.c.; once) 在小鼠中显示外周抗炎和抗伤感受活性。Seselin (3-30 mg/kg; i.g.; once) 改善小鼠盲肠结扎和穿刺引起的脓毒症。Animal Model:Male Swiss mice
Dosage:0.5, 4.5 or 40.5 mg/kg
Administration:Subcutaneous injection; once
Result:Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.
Animal Model:C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model
Dosage:3, 10 and 30 mg/kg
Administration:Intragastric administration, once
Result:Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.
体外研究：
Seselin 对 P-388 和 HT-29 细胞有毒性，ED50 分别为 8.66 和 9.94 μg/mL 。Seselin (5-20 μM; 0.5-24 h) 抑制 LPS 和 IFN-γ 刺激的巨噬细胞的细胞因子输出。Seselin (5-20 μM; 12 h) 抑制 BMDMs 中促炎巨噬细胞标志物 (iNOS、phagocytosis、CD11c) 的表达。Seselin (5-20 μM; 0.5-6 h) 阻断 STAT1 信号通路。
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.
体内研究：
Seselin (0.5-40.5 mg/kg; s.c.; once) 在小鼠中显示外周抗炎和抗伤感受活性。Seselin (3-30 mg/kg; i.g.; once) 改善小鼠盲肠结扎和穿刺引起的脓毒症。Animal Model:Male Swiss mice
Dosage:0.5, 4.5 or 40.5 mg/kg
Administration:Subcutaneous injection; once
Result:Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.
Animal Model:C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model
Dosage:3, 10 and 30 mg/kg
Administration:Intragastric administration, once
Result:Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.
体外研究：
Seselin 对 P-388 和 HT-29 细胞有毒性，ED50 分别为 8.66 和 9.94 μg/mL 。Seselin (5-20 μM; 0.5-24 h) 抑制 LPS 和 IFN-γ 刺激的巨噬细胞的细胞因子输出。Seselin (5-20 μM; 12 h) 抑制 BMDMs 中促炎巨噬细胞标志物 (iNOS、phagocytosis、CD11c) 的表达。Seselin (5-20 μM; 0.5-6 h) 阻断 STAT1 信号通路。
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