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编 号：F378215
分子式：C17H15ClN2O
分子量：298.77
分子式：C17H15ClN2O
分子量：298.77
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CAS No: 52238-35-4
产品详情
生物活性：
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively.
体内研究：
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.Animal Model:Three- to five-month-old C57B1/6 male mice.
Dosage:5 or 10 mg/kg.
Administration:IP.
Result:Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
体外研究：
9-Hydroxyellipticine(9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM.
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively.
体内研究：
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.Animal Model:Three- to five-month-old C57B1/6 male mice.
Dosage:5 or 10 mg/kg.
Administration:IP.
Result:Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
体外研究：
9-Hydroxyellipticine(9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM.
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