产品
编 号：F378092
分子式：C23H30Cl2NNa2O6P
分子量：564.35
分子式：C23H30Cl2NNa2O6P
分子量：564.35
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 52205-73-9
产品详情
生物活性：
Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
体内研究：
Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.Animal Model:Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors
Dosage:4 mg/kg, 12 mg/kg
Administration:Intraperitoneal injection; daily; for 2 weeks
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
Animal Model:Human prostate cancer xenograft PAC120
Dosage:4 or 12 mg/kg, a daily dose for 2 weeks.
Administration:Intraperitoneal injection
Result:Inhibited PAC120 tumor growth 53% by day 35.
体外研究：
Estramustine phosphate sodium (1 μg/ mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate sodium (2 μg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate sodium (0-40 μM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate sodium (10 μM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation.
Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
体内研究：
Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.Animal Model:Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors
Dosage:4 mg/kg, 12 mg/kg
Administration:Intraperitoneal injection; daily; for 2 weeks
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
Animal Model:Human prostate cancer xenograft PAC120
Dosage:4 or 12 mg/kg, a daily dose for 2 weeks.
Administration:Intraperitoneal injection
Result:Inhibited PAC120 tumor growth 53% by day 35.
体外研究：
Estramustine phosphate sodium (1 μg/ mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate sodium (2 μg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate sodium (0-40 μM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate sodium (10 μM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备