产品
编 号:F377189
分子式:C14H17N5O3
分子量:303.32
产品类型
结构图
CAS No: 51940-44-4
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产品详情
生物活性:
Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections.
体内研究:
Pipemidic acid (50 mg/kg) 口服吸收良好,在小鼠、大鼠、犬、猴中血浆峰浓度范围为 4~12 μg/mL。Pipemidic acid 在小鼠单次口服后的平均致死剂量超过 16000 mg/kg。
体外研究:
Pipemidic acid 是 DNA 促旋酶的抑制剂,DNA 促旋酶是一种催化 ATP 依赖性 DNA 负超螺旋的细菌酶。