产品
编 号：F376998
分子式：C15H24N2O
分子量：248.36
分子式：C15H24N2O
分子量：248.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
781
In-stock
200mg
1340
In-stock
500mg
2381
In-stock
结构图
CAS No: 519-02-8
产品详情
生物活性：
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).
体内研究：
Matrine (灌胃，40 和 80 mg/kg，连续 16 天，异种移植雄性C57BL/6小鼠模型) 抑制肿瘤生长和转移而不影响体重。腹膜内注射，每天 5 mg/kg，连续四天) 减轻顺铂诱导的 AKI 小鼠的肾损伤和细胞凋亡，以及减少炎症反应和激活 SIRT3/OPA1 轴并挽救肾线粒体功能障碍。Animal Model:Xenograft male C57BL/6mice model (LLC cells)
Dosage:40 and 80 mg/kg for 16 consecutive days
Administration:Intragastric administration
Result:Inhibited tumors growth.Decreased the ratio of CD206+/F4/80+, promoted the expression of CD4+ and CD8+ T cells, and inhibited the expression of Th2 in tumor and spleen tissues.
Animal Model:Cisplatin-induced acute kidney injury (AKI) mice model
Dosage:5 mg/kg daily for 4 days
Administration:Intraperitoneal injections
Result:Attenuated tubular injury observed in AKI mice, including renal tubular necrosis,formation of tubular casts, cytoplasmic vacuoles and renal infiltrationof inflammatory cells in mice.Decreased serum levels of TNF-a and IL-6 and the phosphorylation of NF-κB, activated SIRT3/OPA1 axis and improved mitochondrial function.
体外研究：
Matrine (0-1.5 mg/mL，24-72 h) 抑制 A549 和 SMMC-7721 细胞的生长。Matrine (25 μg/mL，6 h) 抑制 A549 细胞的迁移。 Matrine (0-1 mg/mL，48 h) 通过降低 A549 和 SMMC-7721 细胞的 Bcl-2/Bax 蛋白比率诱导细胞凋亡。Matrine (0-1 mg/mL，48 h) 抑制miR-182-5p表达并诱导PTC细胞凋亡。 Matrine (10 μM，48 小时) 通过降低 ROS 水平和促炎细胞因子 (包括 IL-1β、IL-6 和 TNF-α) 抑制顺铂诱导的 HK2 细胞氧化损伤和炎症。Matrine (10 μM，48 h) 通过激活 SIRT3/OPA1 通路逆转顺铂诱导的 HK2 细胞的线粒体功能。Matrine (0 -20 nM，12 h) 通过抑制线粒体自噬和 PINK1/Parkin 通路促进 HepG2 细胞凋亡。
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).
体内研究：
Matrine (灌胃，40 和 80 mg/kg，连续 16 天，异种移植雄性C57BL/6小鼠模型) 抑制肿瘤生长和转移而不影响体重。腹膜内注射，每天 5 mg/kg，连续四天) 减轻顺铂诱导的 AKI 小鼠的肾损伤和细胞凋亡，以及减少炎症反应和激活 SIRT3/OPA1 轴并挽救肾线粒体功能障碍。Animal Model:Xenograft male C57BL/6mice model (LLC cells)
Dosage:40 and 80 mg/kg for 16 consecutive days
Administration:Intragastric administration
Result:Inhibited tumors growth.Decreased the ratio of CD206+/F4/80+, promoted the expression of CD4+ and CD8+ T cells, and inhibited the expression of Th2 in tumor and spleen tissues.
Animal Model:Cisplatin-induced acute kidney injury (AKI) mice model
Dosage:5 mg/kg daily for 4 days
Administration:Intraperitoneal injections
Result:Attenuated tubular injury observed in AKI mice, including renal tubular necrosis,formation of tubular casts, cytoplasmic vacuoles and renal infiltrationof inflammatory cells in mice.Decreased serum levels of TNF-a and IL-6 and the phosphorylation of NF-κB, activated SIRT3/OPA1 axis and improved mitochondrial function.
体外研究：
Matrine (0-1.5 mg/mL，24-72 h) 抑制 A549 和 SMMC-7721 细胞的生长。Matrine (25 μg/mL，6 h) 抑制 A549 细胞的迁移。 Matrine (0-1 mg/mL，48 h) 通过降低 A549 和 SMMC-7721 细胞的 Bcl-2/Bax 蛋白比率诱导细胞凋亡。Matrine (0-1 mg/mL，48 h) 抑制miR-182-5p表达并诱导PTC细胞凋亡。 Matrine (10 μM，48 小时) 通过降低 ROS 水平和促炎细胞因子 (包括 IL-1β、IL-6 和 TNF-α) 抑制顺铂诱导的 HK2 细胞氧化损伤和炎症。Matrine (10 μM，48 h) 通过激活 SIRT3/OPA1 通路逆转顺铂诱导的 HK2 细胞的线粒体功能。Matrine (0 -20 nM，12 h) 通过抑制线粒体自噬和 PINK1/Parkin 通路促进 HepG2 细胞凋亡。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备