产品
编 号：F376920
分子式：C38H42N2O6
分子量：622.75
分子式：C38H42N2O6
分子量：622.75
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 518-94-5
产品详情
生物活性：
Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.
体内研究：
Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM.
体外研究：
Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM.Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells.
Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.
体内研究：
Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM.
体外研究：
Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM.Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells.
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