产品
编 号：F376860
分子式：C22H27NO4
分子量：369.45
分子式：C22H27NO4
分子量：369.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 518-69-4
产品详情
生物活性：
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
体内研究：
Corydaline (10 mg/kg；皮下给药；一次) 处理通过显著抑制小鼠的扭体行为显示出镇痛作用。Animal Model:Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid
Dosage:10 mg/kg
Administration:Subcutaneous administration; once
Result:Showed antinociceptive effects in mice.
体外研究：
Corydaline (12.5-50 μM；24 小时) 治疗可通过抑制 COX-2 表达以及 JNK MAPK 和 P38 MAPK 的磷酸化来抑制 EV71 复制，但不会抑制 ERK MAPK。Corydaline 以剂量依赖的方式抑制病毒 RNA 的合成。
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
体内研究：
Corydaline (10 mg/kg；皮下给药；一次) 处理通过显著抑制小鼠的扭体行为显示出镇痛作用。Animal Model:Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid
Dosage:10 mg/kg
Administration:Subcutaneous administration; once
Result:Showed antinociceptive effects in mice.
体外研究：
Corydaline (12.5-50 μM；24 小时) 治疗可通过抑制 COX-2 表达以及 JNK MAPK 和 P38 MAPK 的磷酸化来抑制 EV71 复制，但不会抑制 ERK MAPK。Corydaline 以剂量依赖的方式抑制病毒 RNA 的合成。
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