产品
编 号：F376808
分子式：C4H12N2S2
分子量：152.28
分子式：C4H12N2S2
分子量：152.28
产品类型
规格
价格
是否有货
50mg
552
In-stock
100mg
880
In-stock
250mg
1760
In-stock
500mg
2720
In-stock
结构图
CAS No: 51-85-4
产品详情
生物活性：
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .
体内研究：
Cystamine (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice.Animal Model:R6/2 transgenic HD mice
Dosage:112, 225 mg/kg
Administration:Intraperitoneal or oral, daily
Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
体外研究：
Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione.
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .
体内研究：
Cystamine (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice.Animal Model:R6/2 transgenic HD mice
Dosage:112, 225 mg/kg
Administration:Intraperitoneal or oral, daily
Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
体外研究：
Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione.
产品资料
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