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编 号:F376534
分子式:C21H36N8O7
分子量:512.56
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生物活性:
Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease.

体外研究:
Elastatinal inhibits the binding of acetyl-alanyl-alanyl-alanine pnitroanilide and acetyl-alanyl-alanyl-alanine methyl ester to elastase, with Kis of 0.24 μM and 0.21 μM, respectively.Elastatinal (5-20 μM) suppresses the enhanced osteoclast differentiation by neutrophils.
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