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编 号：F376333
分子式：C16H19N3O5S
分子量：365.4
分子式：C16H19N3O5S
分子量：365.4
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CAS No: 51762-05-1
产品详情
生物活性：
Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 106 μg/mL. Cefroxadine can be used for the research of infection.
体内研究：
Cefroxadine (0-30 mg/kg; p.o. 0 and 3 h after infection) shows a better effect than cephalexin in vivo.Animal Model:Mice with E. coli ML4707 and K. pneumoniae GN6445 infection
Dosage:0-30 mg/kg
Administration:Oral gavage; 0-30 mg/kg; 0 and 3 h after infection
Result:Showed a better effect than cephalexin in vivo with ED50 values of 21.4 and 10.9 mg/kg for E. coli ML4707 and K. pneumoniae GN6445 in vivo.
体外研究：
Cefroxadine (106-108 μg/mL; overnight) shows antibacterial activities against S. aureus, E. coli, S. typhi, S. paratyphi, S. schottmuelleri, K. apneumoniae and P. mirabilis with MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 106 μg/mL.Cefroxadine (104-108 μg/mL; overnight) shows antibacterial activities against 100 E. coli strains with MIC50 and MIC75 values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively.
Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 106 μg/mL. Cefroxadine can be used for the research of infection.
体内研究：
Cefroxadine (0-30 mg/kg; p.o. 0 and 3 h after infection) shows a better effect than cephalexin in vivo.Animal Model:Mice with E. coli ML4707 and K. pneumoniae GN6445 infection
Dosage:0-30 mg/kg
Administration:Oral gavage; 0-30 mg/kg; 0 and 3 h after infection
Result:Showed a better effect than cephalexin in vivo with ED50 values of 21.4 and 10.9 mg/kg for E. coli ML4707 and K. pneumoniae GN6445 in vivo.
体外研究：
Cefroxadine (106-108 μg/mL; overnight) shows antibacterial activities against S. aureus, E. coli, S. typhi, S. paratyphi, S. schottmuelleri, K. apneumoniae and P. mirabilis with MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 106 μg/mL.Cefroxadine (104-108 μg/mL; overnight) shows antibacterial activities against 100 E. coli strains with MIC50 and MIC75 values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively.
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