产品
编 号：F376027
分子式：C26H45NO6S
分子量：499.7
分子式：C26H45NO6S
分子量：499.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 516-50-7
产品详情
生物活性：
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).
体内研究：
Taurodeoxycholic acid (50 mg/kg；腹腔注射；每天 1 次，共 34 天) 预防亨廷顿舞蹈病 (HD) 大鼠模型的神经病理和相关的行为缺陷。Taurodeoxycholic acid (500 mg/kg；皮下注射；每 3 天 1 次，共 7 周) 导致 R6/2 转基因 HD 小鼠纹状体神经病理的显著降低。Animal Model:Huntington's disease model in mouse
Dosage:50 mg/kg
Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.Significantly improved locomotor and sensorimotor deficits.
体外研究：
Taurodeoxycholic acid (50 μM，100 μM；4 h)增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡。Taurodeoxycholic acid (400 μM；18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡。
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).
体内研究：
Taurodeoxycholic acid (50 mg/kg；腹腔注射；每天 1 次，共 34 天) 预防亨廷顿舞蹈病 (HD) 大鼠模型的神经病理和相关的行为缺陷。Taurodeoxycholic acid (500 mg/kg；皮下注射；每 3 天 1 次，共 7 周) 导致 R6/2 转基因 HD 小鼠纹状体神经病理的显著降低。Animal Model:Huntington's disease model in mouse
Dosage:50 mg/kg
Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.Significantly improved locomotor and sensorimotor deficits.
体外研究：
Taurodeoxycholic acid (50 μM，100 μM；4 h)增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡。Taurodeoxycholic acid (400 μM；18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡。
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