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编 号：F375942
分子式：C18H18N6O5S2
分子量：462.5
分子式：C18H18N6O5S2
分子量：462.5
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CAS No: 51627-14-6
产品详情
生物活性：
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection.
体内研究：
Cefatrizine (BL-S-640) (0.2, 1, 5, 25 mg/kg; p.o.; 4 times daily for 3 days) reduces the number of infecting organisms in the bladder and the kidneys in P. mirabilis intracystically infected model.Animal Model:MaleSwiss-Webster mice (19-21 g; P. mirabilis intracystically infected model).
Dosage:0.2, 1, 5, 25 mg/kg
Administration:Oral administration; 4 times daily for 3 days.
Result:Reduced the number of infecting organisms to less than 1,000 in the bladder when 1 mg/kg, and in the kidneys when 0.2 mg/kg.
体外研究：
Cefatrizine (0-100 μM; 24 h) causes a remarkable anti-proliferative effect on MCF-7 and MDA-MB-436 cell growth in a dose-dependent manner.Cefatrizine (30 μM; 12 h) induces ER stress in breast cancer cells.Cefatrizine (12, 24, 36 h) increases level of CHOP (marker of ER stress induced apoptosis) and promotes expressions of core proteins in eEF2K-modulated ER stress pathways (Bip, p-PERK, XBP-1S and p-JNK) in MCF-7 and MDA-MB-436 cells.
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection.
体内研究：
Cefatrizine (BL-S-640) (0.2, 1, 5, 25 mg/kg; p.o.; 4 times daily for 3 days) reduces the number of infecting organisms in the bladder and the kidneys in P. mirabilis intracystically infected model.Animal Model:MaleSwiss-Webster mice (19-21 g; P. mirabilis intracystically infected model).
Dosage:0.2, 1, 5, 25 mg/kg
Administration:Oral administration; 4 times daily for 3 days.
Result:Reduced the number of infecting organisms to less than 1,000 in the bladder when 1 mg/kg, and in the kidneys when 0.2 mg/kg.
体外研究：
Cefatrizine (0-100 μM; 24 h) causes a remarkable anti-proliferative effect on MCF-7 and MDA-MB-436 cell growth in a dose-dependent manner.Cefatrizine (30 μM; 12 h) induces ER stress in breast cancer cells.Cefatrizine (12, 24, 36 h) increases level of CHOP (marker of ER stress induced apoptosis) and promotes expressions of core proteins in eEF2K-modulated ER stress pathways (Bip, p-PERK, XBP-1S and p-JNK) in MCF-7 and MDA-MB-436 cells.
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