产品
编 号：F375907
分子式：C8H11NO2
分子量：153.18
分子式：C8H11NO2
分子量：153.18
产品类型
规格
价格
是否有货
10mg
询价
询价
结构图
CAS No: 51-61-6
产品详情
生物活性：
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
体内研究：
Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF.Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors
Dosage:50 mg/kg
Administration:I.p. injection; 7 days
Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
体外研究：
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24hours).
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
体内研究：
Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF.Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors
Dosage:50 mg/kg
Administration:I.p. injection; 7 days
Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
体外研究：
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 μM; 24hours).
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