产品
编 号：F375500
分子式：C25H24ClN3O3S
分子量：481.99
分子式：C25H24ClN3O3S
分子量：481.99
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 515141-51-2
产品详情
生物活性：
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.
体内研究：
GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.Animal Model:High fat diet-induced obese AKR/J mice
Dosage:0.3, 3, and 15 mg/kg
Administration:Orally, qd,12 days
Result:Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
体外研究：
GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13?nM.
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.
体内研究：
GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.Animal Model:High fat diet-induced obese AKR/J mice
Dosage:0.3, 3, and 15 mg/kg
Administration:Orally, qd,12 days
Result:Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
体外研究：
GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13?nM.
产品资料
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