产品
编 号：F375304
分子式：C21H22O5
分子量：354.4
分子式：C21H22O5
分子量：354.4
产品类型
规格
价格
是否有货
1mg
询价
询价
2mg
询价
询价
结构图
CAS No: 514-67-0
产品详情
生物活性：
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.
体内研究：
Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear.Animal Model:Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:8, 32 mg/kg
Administration:I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).No significant difference was observed on the body weight.
体外研究：
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.Rubropunctatin (0.75-8.0 μg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.
体内研究：
Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice.Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear.Animal Model:Male nude mice (5 weeks) are inoculated with BGC-823 cells
Dosage:8, 32 mg/kg
Administration:I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).No significant difference was observed on the body weight.
体外研究：
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1.Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells.Rubropunctatin (0.75-8.0 μg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity.
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