产品
编 号：F375300
分子式：C21H29NO
分子量：311.46
分子式：C21H29NO
分子量：311.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 514-65-8
产品详情
生物活性：
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
体内研究：
Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells. Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.Animal Model:Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells
Dosage:10 mg/kg
Administration:Intraperitoneal injection; everyday; 3 weeks
Result:Tumor size reduced by 83%.
Animal Model:Male Wistar rats (200-250 g)
Dosage:8 mg/kg
Administration:Intraperitoneal injection; every 8 hours; 10 days
Result:Reduced late seizures by about three times with no affecting emotional memory damage.
体外研究：
Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.
体内研究：
Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells. Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.Animal Model:Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells
Dosage:10 mg/kg
Administration:Intraperitoneal injection; everyday; 3 weeks
Result:Tumor size reduced by 83%.
Animal Model:Male Wistar rats (200-250 g)
Dosage:8 mg/kg
Administration:Intraperitoneal injection; every 8 hours; 10 days
Result:Reduced late seizures by about three times with no affecting emotional memory damage.
体外研究：
Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
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