产品
编 号：F374738
分子式：C7H16ClN5O4
分子量：269.69
分子式：C7H16ClN5O4
分子量：269.69
产品类型
规格
价格
是否有货
100mg
400
In-stock
500mg
720
In-stock
1g
1080
In-stock
5g
1560
In-stock
10g
1840
In-stock
结构图
CAS No: 51298-62-5
产品详情
生物活性：
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
体内研究：
L-NAME hydrochloride 可用于动物建模，构建心脑血管疾病模型。L-NAME hydrochloride 是一种经典的高血压建模剂，可减少动物体内一氧化氮 (NO) 的释放，并具有抑制内皮一氧化氮合酶 (eNOS) 的能力。通常使用大鼠和小鼠作为动物模型。L-NAME盐酸盐诱导剂量参考：(1) 模型动物：Swiss Webster 雄性小鼠（6周）高血压模型：400 mg/kg/day，i.p，7 天(2) 模型动物：雄性Sprague-Dawley(SD)大鼠高血压模型：40 mg/kg，dinking，5周Animal Model: Male Sprague-Dawley (SD) rats
Dosage:40 mg/kg, 5 weeks
Administration:drinking water
Result:Induced hypertension with body weight loss and high blood pressure.
体外研究：
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with Nw-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
体内研究：
L-NAME hydrochloride 可用于动物建模，构建心脑血管疾病模型。L-NAME hydrochloride 是一种经典的高血压建模剂，可减少动物体内一氧化氮 (NO) 的释放，并具有抑制内皮一氧化氮合酶 (eNOS) 的能力。通常使用大鼠和小鼠作为动物模型。L-NAME盐酸盐诱导剂量参考：(1) 模型动物：Swiss Webster 雄性小鼠（6周）高血压模型：400 mg/kg/day，i.p，7 天(2) 模型动物：雄性Sprague-Dawley(SD)大鼠高血压模型：40 mg/kg，dinking，5周Animal Model: Male Sprague-Dawley (SD) rats
Dosage:40 mg/kg, 5 weeks
Administration:drinking water
Result:Induced hypertension with body weight loss and high blood pressure.
体外研究：
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with Nw-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.
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