产品
编 号：F374493
分子式：C14H9I3O4
分子量：621.93
分子式：C14H9I3O4
分子量：621.93
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 51-24-1
产品详情
生物活性：
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication..
体内研究：
Tiratricol (0.2 mg/kg/day; po; 6 天) 预处理，在小鼠中能够预防 YFV 感染，改善小鼠健康状况。Animal Model:C57BL/6 mice infected with YFV
Dosage:0.2 mg/kg/day
Administration:po; day 0–6 post infection (dpi) or from 2 days before infection to 6 dpi
Result:Significantly reduce virus titers and protein expression.Restored body weight and improved the survival rate of YFV-infected mice by 40%.
体外研究：
Tiratricol (10, 40 μM; 24 h) 剂量依赖性抑制 YFV 感染 Huh-7 细胞，还降低病毒非结构蛋白 (NS3) 的表达。
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication..
体内研究：
Tiratricol (0.2 mg/kg/day; po; 6 天) 预处理，在小鼠中能够预防 YFV 感染，改善小鼠健康状况。Animal Model:C57BL/6 mice infected with YFV
Dosage:0.2 mg/kg/day
Administration:po; day 0–6 post infection (dpi) or from 2 days before infection to 6 dpi
Result:Significantly reduce virus titers and protein expression.Restored body weight and improved the survival rate of YFV-infected mice by 40%.
体外研究：
Tiratricol (10, 40 μM; 24 h) 剂量依赖性抑制 YFV 感染 Huh-7 细胞，还降低病毒非结构蛋白 (NS3) 的表达。
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