产品
编 号：F374332
分子式：C27H44O4
分子量：432.64
分子式：C27H44O4
分子量：432.64
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
20mg
询价
询价
结构图
CAS No: 511-96-6
产品详情
生物活性：
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.
体内研究：
Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) showsrat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).
体外研究：
When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC50 value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, the IC50 value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC50 value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC50 value of 22.0 μM.
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.
体内研究：
Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) showsrat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).
体外研究：
When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC50 value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, the IC50 value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC50 value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC50 value of 22.0 μM.
产品资料
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