产品
编 号：F374311
分子式：C21H25N
分子量：291.43
分子式：C21H25N
分子量：291.43
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CAS No: 5118-29-6
产品详情
生物活性：
Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety.
体内研究：
Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats.Animal Model:Male and female Wistar rats
Dosage:10, 30 and 90 mg/kg
Administration:Oral gavage; 10-90 mg/kg daily; for 3 months
Result:Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
体外研究：
Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets.
Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety.
体内研究：
Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats.Animal Model:Male and female Wistar rats
Dosage:10, 30 and 90 mg/kg
Administration:Oral gavage; 10-90 mg/kg daily; for 3 months
Result:Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
体外研究：
Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets.
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