产品
编 号：F374178
分子式：C21H21N5
分子量：343.42
分子式：C21H21N5
分子量：343.42
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 511514-03-7
产品详情
生物活性：
0990CL is a?specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.
体外研究：
0990CL?(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi?mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL?(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi?and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.
0990CL is a?specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.
体外研究：
0990CL?(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi?mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL?(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi?and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.
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