产品
编 号：F374177
分子式：C7H9ClN2O
分子量：172.61
分子式：C7H9ClN2O
分子量：172.61
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 51-15-0
产品详情
生物活性：
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning.
体内研究：
Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice.Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)
Dosage:10, 50, 100, and 150 mg/kg
Administration:Intramuscular administration, once
Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning.
体内研究：
Pralidoxime chloride (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice.Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)
Dosage:10, 50, 100, and 150 mg/kg
Administration:Intramuscular administration, once
Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
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