产品
编 号：F373539
分子式：C23H30O5
分子量：386.48
分子式：C23H30O5
分子量：386.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 50980-32-0
产品详情
生物活性：
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
体内研究：
Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function.Animal Model:Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks
Dosage:10 mg/kg
Administration:Oral administration for 28 days
Result:Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.
体外研究：
Ankaflavin (0-50 μg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells.Ankaflavin (0-30 μg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner.Ankaflavin (25 μg/mL, 48 h) induces Hep G2 cell apoptosis.
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
体内研究：
Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function.Animal Model:Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks
Dosage:10 mg/kg
Administration:Oral administration for 28 days
Result:Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.
体外研究：
Ankaflavin (0-50 μg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells.Ankaflavin (0-30 μg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner.Ankaflavin (25 μg/mL, 48 h) induces Hep G2 cell apoptosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备