产品
编 号:F373159
分子式:C29H42O10
分子量:550.64
产品类型
结构图
CAS No: 508-75-8
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产品详情
生物活性:
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.
体内研究:
Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis.
体外研究:
Convallatoxin induces HaCaT cell necroptosis.