产品
编 号:F373032
分子式:C31H50O4
分子量:486.73
产品类型
结构图
CAS No: 508-24-7
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产品详情
生物活性:
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.
体外研究:
Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM).Tumulosic acid decreases in LL-37 production in human keratinocytes. Tumulosic acidshows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM).