产品
编 号：F372592
分子式：C34H57BrN2O4
分子量：637.73
分子式：C34H57BrN2O4
分子量：637.73
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
640
In-stock
100mg
960
In-stock
结构图
CAS No: 50700-72-6
产品详情
生物活性：
Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia.
体内研究：
Vecuronium bromide (Intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats.Animal Model:Wister rats weighing 250-350 g
Dosage:0-5 μM
Administration:Intravenous injection; every 30 min; 2 hours
Result:Significantly diminished CSNA response to hypoxia at the concentration of 5 μM and reduced carotid sinus nerve response to ACh at 0.5 μM.
体外研究：
Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells.Vecuronium bromide (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner.Vecuronium bromide (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin.
Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia.
体内研究：
Vecuronium bromide (Intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats.Animal Model:Wister rats weighing 250-350 g
Dosage:0-5 μM
Administration:Intravenous injection; every 30 min; 2 hours
Result:Significantly diminished CSNA response to hypoxia at the concentration of 5 μM and reduced carotid sinus nerve response to ACh at 0.5 μM.
体外研究：
Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells.Vecuronium bromide (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner.Vecuronium bromide (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin.
产品资料
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