产品
编 号：F372353
分子式：C24H46O2
分子量：366.62
分子式：C24H46O2
分子量：366.62
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
250mg
询价
询价
500mg
询价
询价
结构图
CAS No: 506-37-6
产品详情
生物活性：
Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases.
体内研究：
Nervonic acid (20, 40, 60 mg/kg, 灌胃, 7 天) 在 PD 小鼠模型中保护运动系统免受运动障碍。Nervonic acid (5, 50, 100 mg/kg, 溶解在玉米油中灌胃，7 天) 通过抑制 DSS 诱导结肠炎小鼠 NF-κB 信号通路改善结肠炎症。Animal Model:MPTP-induced PD mice model
Dosage:20, 40, 60 mg/kg
Administration:i.g. for 7 days
Result:Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response.
Animal Model:DSS-induced colitis mice model
Dosage:5, 50, 100 mg/kg
Administration:i.g. for 7 days
Result:Improved the symptoms of diarrhea, weight loss and fecal occidental blood.Reduced the levels of COX-2 and iNOS.
体外研究：
Nervonic acid (0.01 μM, 48 h) 可提高 PC-12 细胞活力，在大脑中发挥神经保护介质的作用。Nervonic acid (12.5, 25, 50 μM, 24 h ) 可降低 LPS 诱导的 RAW264.7 细胞的炎症反应，抑制炎症相关关键信号通路的激活。
Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases.
体内研究：
Nervonic acid (20, 40, 60 mg/kg, 灌胃, 7 天) 在 PD 小鼠模型中保护运动系统免受运动障碍。Nervonic acid (5, 50, 100 mg/kg, 溶解在玉米油中灌胃，7 天) 通过抑制 DSS 诱导结肠炎小鼠 NF-κB 信号通路改善结肠炎症。Animal Model:MPTP-induced PD mice model
Dosage:20, 40, 60 mg/kg
Administration:i.g. for 7 days
Result:Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response.
Animal Model:DSS-induced colitis mice model
Dosage:5, 50, 100 mg/kg
Administration:i.g. for 7 days
Result:Improved the symptoms of diarrhea, weight loss and fecal occidental blood.Reduced the levels of COX-2 and iNOS.
体外研究：
Nervonic acid (0.01 μM, 48 h) 可提高 PC-12 细胞活力，在大脑中发挥神经保护介质的作用。Nervonic acid (12.5, 25, 50 μM, 24 h ) 可降低 LPS 诱导的 RAW264.7 细胞的炎症反应，抑制炎症相关关键信号通路的激活。
产品资料
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